HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → 4'-[2-Ethoxy-5-(hydroxyiminomethyl)-4-vinylimidazol-1-ylmethyl]-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4'-(2-Ethoxy-5-formyl-4-vinylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester | HCID 59596730 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4'-[2-Ethoxy-5-(hydroxyiminomethyl)-4-vinylimidazol-1-ylmethyl]-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester | HCID 72266017 | 91.4% |
Reaction Steps
A solution of compound A (17.9 g, 39.7 mmol), hydroxylamine (3.9 g, 119 mmol), pyridine (200 mL), and water (100 mL) were combined. After stirring overnight, water (50 mL) was added and the precipitate was filtered to yield compound B as an off-white solid (16.9 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637562B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-410a16fda33849d8bdbb87c5d1aeec28 |
| Source note | uspto-grants-2014_01 |