反应详情

Then the entire crude reaction product was poured into water (30 ml), and subjected to extraction with ethyl acetate. After separation of an organic layer, drying with magnesium sulfate was carried out and concentration under reduced pressure was conducted. Then thereto was added 1.46 g (10 mmol) of benzotrifluoride, and it was confirmed by a 19F-NMR analysis based on benzotrifluoride that 1-(1,1,2,2-tetrafluoroethyl)imidazole had been produced at yield of 7% and 1-(1,2,2-trifluoroethenyl)imidazole had been produced at yield of 39%.

1. customThen the entire crude reaction product
2. extractionsubjected to extraction with ethyl acetate
3. customAfter separation of an organic layer
4. dry with materialdrying with magnesium sulfate
5. concentrationconcentration under reduced pressure