Methylamine → HCID 58075322, compound

HRID 475828Notes

Reaction equation

HRID 475828 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH2:11][O:10][CH2:9][CH:8]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[CH:13]=3)[C:6]=2[N:7]=1.[CH3:21][NH2:22]>>[Cl:1][C:2]1[N:3]=[C:4]([NH:22][CH3:21])[C:5]2[CH2:11][O:10][CH2:9][CH:8]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[CH:13]=3)[C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 58075539HCID 58075539, compound

Product 1

HCID 58075322HCID 58075322, compound

Procedure

2,4-dichloro-8-(3,4-difluorophenyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine (Preparation Y) was reacted as described in Preparation Xa with methanamine to give 2-chloro-8-(3,4-difluorophenyl)-N-methyl-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-amine (Preparation Yc). LC-MS (M+H)+=312.3.

Sources & evidence

ORD record
ord-e722facb5d894d86aec826d24c992877
Source dataset
uspto-grants-2014_01
Patent number
US08637525B2

Reaction notes

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