反应详情

140 mg of [5-(3,5-dichlorophenylthio)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-4-yl]-phenyl-methanone was treated with 4 ml of trifluoroacetic acid. The solution was then heated at reflux for 2 h. The solvent was evaporated under reduced pressure. The residue was then partitioned between dichloromethane/saturated sodium hydrogen carbonate, washed with brine then dried over anhydrous magnesium sulphate, filtered and evaporated to give 75 mg of [5-(3,5-dichlorophenylthio)-3-methyl-1H-pyrazol-4-yl]-phenyl-methanone as a yellow solid which was used without further purification. Mass spectrum (ES) m/z 363[M+H]+.

1. temperatureThe solution was then heated
2. temperatureat reflux for 2 h
3. customThe solvent was evaporated under reduced pressure
4. customThe residue was then partitioned between dichloromethane/saturated sodium hydrogen carbonate
5. washwashed with brine
6. dry with materialthen dried over anhydrous magnesium sulphate
7. filtrationfiltered
8. customevaporated