1-(4-Fluorophenyl)cyclobutanecarboxylic acid → (R)-2-(7-(1-(4-fluorophenyl)-N-methylcyclobutanecarboxamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid

HRID 476257Notes

Reaction equation

HRID 476257 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]([OH:14])=O)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:15][NH:16][C@H:17]1[CH2:36][N:21]2[C:22]3[C:27]([C:28]([CH2:29][C:30]([O:32]CCC)=[O:31])=[C:20]2[CH2:19][CH2:18]1)=[CH:26][CH:25]=[CH:24][CH:23]=3>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:12]([N:16]([CH3:15])[C@H:17]3[CH2:36][N:21]4[C:22]5[C:27]([C:28]([CH2:29][C:30]([OH:32])=[O:31])=[C:20]4[CH2:19][CH2:18]3)=[CH:26][CH:25]=[CH:24][CH:23]=5)=[O:14])[CH2:9][CH2:10][CH2:11]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 167690171-(4-Fluorophenyl)cyclobutanecarboxylic acidHCID 86655417propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate

Product 1

HCID 53248760(R)-2-(7-(1-(4-fluorophenyl)-N-methylcyclobutanecarboxamido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid

Procedure

The title compound was prepared using analogous procedures described in Example 1 (Method A) from 1-(4-fluorophenyl)cyclobutanecarboxylic acid and propyl [(7R)-7-(methylamino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 435.

Sources & evidence

ORD record
ord-a0728bbecc164894ab0dc63ee6fc5013
Source dataset
uspto-grants-2014_01
Patent number
US08637671B2

Reaction notes

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