HRID476355

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)ON1C(=O)CCC1=O)C(=O)OC(C)(C)C

HCID86644531

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)ON1C(=O)CCC1=O)C(=O)O

HCID58419214

未命名化合物

PROCEDURE

实验过程

Alternatively, the acylation reagent can be prepared employing a solid phase method to prepare the intermediate 19-((S)-1-tert-butoxycarbonyl-3-{2-[2-({2-[2-(2,5-dioxo-pyrrolidin-1-yloxycarbonylmethoxy)ethoxy]ethylcarbamoyl}methoxy)ethoxy]ethylcarbamoyl}propyl-carbamoyl)nonadecanoic acid tert-butyl ester (alternative name: tBu-Eicosanedioyl-gGlu(OtBu)-OEG-OEG-OH) as described in WO 2009/022005 followed by activation as N-hydroxysuccinimide ester and TFA cleavage (last two steps above).

WORKUP

后处理

customAlternatively, the acylation reagent can be prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e280a650e3f04adeb071b38249dcff87
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08637647B2
来源说明: uspto-grants-2014_01

反应 SMILES

C([O:5][C:6](=[O:68])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25](=[O:67])[NH:26][C@H:27]([C:60]([O:62]C(C)(C)C)=[O:61])[CH2:28][CH2:29][C:30](=[O:59])[NH:31][CH2:32][CH2:33][O:34][CH2:35][CH2:36][O:37][CH2:38][C:39](=[O:58])[NH:40][CH2:41][CH2:42][O:43][CH2:44][CH2:45][O:46][CH2:47][C:48]([O:50][N:51]1[C:55](=[O:56])[CH2:54][CH2:53][C:52]1=[O:57])=[O:49])(C)(C)C.C(O)(C(F)(F)F)=O>>[C:60]([C@@H:27]([NH:26][C:25]([CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:6]([OH:68])=[O:5])=[O:67])[CH2:28][CH2:29][C:30](=[O:59])[NH:31][CH2:32][CH2:33][O:34][CH2:35][CH2:36][O:37][CH2:38][C:39](=[O:58])[NH:40][CH2:41][CH2:42][O:43][CH2:44][CH2:45][O:46][CH2:47][C:48]([O:50][N:51]1[C:55](=[O:56])[CH2:54][CH2:53][C:52]1=[O:57])=[O:49])([OH:62])=[O:61]