Potassium Carbonate → Ethyl (N-methyl-3-trifluoromethylbenzylsulfonamido)acetate

HRID 476519Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 476519
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH2:6][S:7](Cl)(=[O:9])=[O:8].[CH2:16]([O:18][C:19](=[O:23])[CH2:20][NH:21][CH3:22])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>O>[CH3:22][N:21]([CH2:20][C:19]([O:18][CH2:16][CH3:17])=[O:23])[S:7]([CH2:6][C:5]1[CH:11]=[CH:12][CH:13]=[C:3]([C:2]([F:15])([F:14])[F:1])[CH:4]=1)(=[O:9])=[O:8]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 95849Glycine, N-methyl-, ethyl esterHCID 27946463-(Trifluoromethyl)phenylmethanesulfonyl chloride

Produkt 1

HCID 15118078Ethyl (N-methyl-3-trifluoromethylbenzylsulfonamido)acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

In this example, 22 g of 3-trifluoromethylbenzylsulfonyl chloride was added cautiously to a solution containing 27 g of the hydrochloride salt of sarcosine ethyl ester and 12 g of potassium carbonate in 90 ml of water at room temperature. The reaction mixture was heated to about 70° C. and maintained at this temperature for about four hours. The mixture was allowed to cool and then extracted with ethyl ether. The ethyl ether extract was dried over magnesium sulfate, filtered, and evaporated to dryness yielding 9.5 g of the title compound as an off-white solid.

Aufarbeitung

  1. temperaturemaintained at this temperature for about four hours
  2. temperatureto cool
  3. extractionextracted with ethyl ether
  4. extractionThe ethyl ether extract
  5. dry with materialwas dried over magnesium sulfate
  6. filtrationfiltered
  7. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-83bc17cc94464749af416e1a13827d0e
Quelldatensatz
uspto-grants-1989_12
Patentnummer
US04885027

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