Ammonium Hydroxide → (N-methyl-3-trifluoromethylbenzylsulfonamido)acetamide. Hydrate

Participants

Reaction Conditions

Reaction Steps

In this example, 3.39 g of ethyl (N-methyl-3-trifluoromethylbenzylsulfonamido)acetate was ground to a powder and combined with about 50 ml of ammonium hydroxide at room temperature. The reaction mixture was heated to about 40° C. and maintained at this temperature for about three hours. The precipitate was collected, washed with water and triturated with ethyl ether to afford 1.4 g of white solid; m.p. 156° to 159° C.

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