Ammonium Hydroxide → (N-methyl-3-trifluoromethylbenzylsulfonamido)acetamide. Hydrate

HRID 476520Notes

Reaction equation

HRID 476520 reaction equation
[CH3:1][N:2]([CH2:17][C:18]([O:20]CC)=O)[S:3]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)(=[O:5])=[O:4].[OH-].[NH4+:24]>>[OH2:4].[CH3:1][N:2]([CH2:17][C:18]([NH2:24])=[O:20])[S:3]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)(=[O:5])=[O:4]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 15118078Ethyl (N-methyl-3-trifluoromethylbenzylsulfonamido)acetate

Product 1

HCID 131716203(N-methyl-3-trifluoromethylbenzylsulfonamido)acetamide. Hydrate

Conditions

Temperature
40 °C

Procedure

In this example, 3.39 g of ethyl (N-methyl-3-trifluoromethylbenzylsulfonamido)acetate was ground to a powder and combined with about 50 ml of ammonium hydroxide at room temperature. The reaction mixture was heated to about 40° C. and maintained at this temperature for about three hours. The precipitate was collected, washed with water and triturated with ethyl ether to afford 1.4 g of white solid; m.p. 156° to 159° C.

Workup

  1. temperaturemaintained at this temperature for about three hours
  2. customThe precipitate was collected
  3. washwashed with water
  4. customtriturated with ethyl ether

Sources & evidence

ORD record
ord-8490cd83506e4f7ba30a8556c21c7c94
Source dataset
uspto-grants-1989_12
Patent number
US04885027

Reaction notes

Loading…