Hydrochloric Acid → HCID 22841177, compound

Participants

Reaction Steps

A stirred solution of (F) (from above) in fresh THF (75ml.) was treated with lN HCl (15 ml.) The mixture was deaerated under a nitrogen atmosphere and stirred at ambient temperatures until tlc analysis indicated no compound (F) remained. The mixture was transferred to a separatory funnel with methylene chloride (300 ml ). washed lX with water (300 ml.), and the aqueous layer re-extracted 2X with methylene chloride. The organic layers were combined and washed lX with water and concentrated in vacuo to compound (G) as an oil which was used immediately in the following step.

Provenance & Evidence