Hydrochloric Acid → HCID 22841177, compound

HRID 476557Notes

Reaction equation

HRID 476557 reaction equation
C(OC([O:6][C@H:7]([C@H:10]([CH3:14])[CH2:11][S:12][CH3:13])[CH:8]=[O:9])C)C.Cl.C(Cl)Cl>C1COCC1>[OH:6][C@H:7]([C@H:10]([CH3:14])[CH2:11][S:12][CH3:13])[CH:8]=[O:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 22841175HCID 22841175, compound2×

Product 1

HCID 22841177HCID 22841177, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A stirred solution of (F) (from above) in fresh THF (75ml.) was treated with lN HCl (15 ml.) The mixture was deaerated under a nitrogen atmosphere and stirred at ambient temperatures until tlc analysis indicated no compound (F) remained. The mixture was transferred to a separatory funnel with methylene chloride (300 ml ). washed lX with water (300 ml.), and the aqueous layer re-extracted 2X with methylene chloride. The organic layers were combined and washed lX with water and concentrated in vacuo to compound (G) as an oil which was used immediately in the following step.

Workup

  1. washwashed lX with water (300 ml.)
  2. extractionthe aqueous layer re-extracted 2X with methylene chloride
  3. washwashed lX with water
  4. concentrationconcentrated in vacuo to compound (G) as an oil which

Sources & evidence

ORD record
ord-768733067b114ea0ac572497fdf282c8
Source dataset
uspto-grants-1989_12
Patent number
US04885276

Reaction notes

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