Hydrochloric Acid → HCID 70382933, compound

HRID 476562Notes

Reaction equation

HRID 476562 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]3[CH2:21][CH2:20][S:19](=[O:23])(=[O:22])[NH:18][CH2:17]3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])C.Cl>>[OH2:3].[O:23]=[S:19]1(=[O:22])[CH2:20][CH2:21][CH:16]([C:13]2[CH:12]=[CH:11][C:10]([N:7]3[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]3)=[CH:15][CH:14]=2)[CH2:17][NH:18]1.[O:23]=[S:19]1(=[O:22])[CH2:20][CH2:21][CH:16]([C:13]2[CH:12]=[CH:11][C:10]([N:7]3[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]3)=[CH:15][CH:14]=2)[CH2:17][NH:18]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19837959HCID 19837959, compound

Product 1

HCID 70382933HCID 70382933, compoundYield 53%

Procedure

A mixture of the product of part (ii) (1.3 g, 3.8 mmole) and 5N hydrochloric acid (15 ml) was heated under reflux for 2 hous. The resulting mixture was concentrated under reduced pressure, the residue diluted with water (10 ml), neutralised with aqueous sodium bicarbonate and extracted into methylene chloride. After drying over magnesium sulphate, the organic phase was concentrated under reduced pressure to yield the title compound as a white solid, (0.6 g, 53%), m.p. 172°-173°.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hous
  3. concentrationThe resulting mixture was concentrated under reduced pressure
  4. additionthe residue diluted with water (10 ml)
  5. extractionextracted into methylene chloride
  6. dry with materialAfter drying over magnesium sulphate
  7. concentrationthe organic phase was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c6d087f56e1c4a9a951997c4013e2ea6
Source dataset
uspto-grants-1989_12
Patent number
US04885294

Reaction notes

Loading…