1H-1,2,4-Triazole, 1-[[2-(2,4-dichlorophenyl)oxiranyl]methyl]- → 3-(4-[4-Aminophenyl]-cis-2,5-dimethylpiperazin-1-yl)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

Participants

Reaction Steps

A mixture of the product of part (i) (2.7 g, 11 mmole) and 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl) oxirane (2.7 g, 10 mmole) in n-pentanol (30 ml) was heated under reflux for 48 hours. The solvent was then removed under reduced pressure and the residue suspended in hot ethyl acetate. After cooling, the insoluble material was removed by filtration to yield diastereomer I of the title compound (1.1 g, 22%), m.p. 212°.

Provenance & Evidence