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HRID476565

反应详情

EQUATION

反应方程式

HRID 476565 的结构方程式

REACTANTS

反应物

2
结构：Clc1ccc(C2(Cn3cncn3)CO2)c(Cl)c1
HCID10423229

1H-1,2,4-Triazole, 1-[[2-(2,4-dichlorophenyl)oxiranyl]methyl]-

C11H9Cl2N3O

结构：C[C@H]1CN(c2ccc([N+](=O)[O-])cc2)[C@@H](C)CN1
HCID70383030

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1CN(c2ccc(N)cc2)[C@@H](C)CN1CC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl
HCID70382687

未命名化合物

收率 23.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCCO
溶剂HCID6276

1-Pentanol

C5H12O

PROCEDURE

实验过程

A mixture of the product of part (i) (2.7 g, 11 mmole) and 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl) oxirane (2.7 g, 10 mmole) in n-pentanol (30 ml) was heated under reflux for 48 hours. The solvent was then removed under reduced pressure and the residue suspended in hot ethyl acetate. After cooling, the insoluble material was removed by filtration to yield diastereomer I of the title compound (1.1 g, 22%), m.p. 212°.

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customThe solvent was then removed under reduced pressure
  4. temperatureAfter cooling
  5. customthe insoluble material was removed by filtration