Methyl 2-hydroxy-3-phenylpropanoate → 2-{3,5-Dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-yloxy}-3-phenyl-propionic acid methyl ester

HRID 47660Notes

Reaction equation

HRID 47660 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[N:17]=[C:18]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=4)[O:19][C:20]=3[CH3:21])=[CH:12][CH:11]=2)[CH:5]=[C:6]([Br:9])[C:7]=1[OH:8].[CH3:32][O:33][C:34](=[O:44])[CH:35]([CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)O>>[CH3:32][O:33][C:34](=[O:44])[CH:35]([O:8][C:7]1[C:6]([Br:9])=[CH:5][C:4]([C:10]2[CH:11]=[CH:12][C:13]([C:16]3[N:17]=[C:18]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([F:29])([F:31])[F:30])=[CH:24][CH:23]=4)[O:19][C:20]=3[CH3:21])=[CH:14][CH:15]=2)=[CH:3][C:2]=1[Br:1])[CH2:37][C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1

Participants

3

Reactant 2

HCID 518800Methyl 2-hydroxy-3-phenylpropanoateHCID 9915604HCID 9915604, compound

Product 1

HCID 104398122-{3,5-Dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-yloxy}-3-phenyl-propionic acid methyl ester

Procedure

The title compound was prepared from 3,5-dibromo-4′-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol, and 3-phenyllactic acid methyl ester in substantially the same manner, as described in Example 7, and was obtained as a white solid, mp 70-72° C.; MS m/e 713 (M+);

Workup

  1. customwas obtained as a white solid, mp 70-72° C.

Sources & evidence

ORD record
ord-974ffee9d4864284a9c22034d5735e22
Source dataset
uspto-grants-2004_03
Patent number
US06699896B1

Reaction notes

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