4-Acetamidobenzaldehyde → HCID 86743545, compound

HRID 476607Notes

Reaction equation

HRID 476607 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:6][C:5]2=[S:18].[C:19]([NH:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=1)(=[O:21])[CH3:20]>N1CCCCC1>[C:19]([NH:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]=[C:6]2[C:5](=[S:18])[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([CH3:1])[CH:3]=3)[O:8][CH:7]2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:25][CH:24]=1)(=[O:21])[CH3:20]

Participants

4

Reactant 2

HCID 739424-AcetamidobenzaldehydeHCID 86743546HCID 86743546, compound

Product 1

HCID 86743545HCID 86743545, compound

Reagents, catalysts & solvents 1

HCID 8082PiperidineCatalyst

Procedure

A solid mixture of 10 g 6-methyl-thioflavanone, 13 g 4-acetylaminobenzaldehyde and 8 drops piperidine is heated at 150°-160° C. for 3 hours. After allowing to cool, the crude brown glass is crystallized from ethanol. Pure 3-(4-acetylaminobenzylidene)-6-methyl-thioflavanone is obtained as a yellow solid; m.p. 197°-198° C.

Workup

  1. temperatureis heated at 150°-160° C. for 3 hours
  2. temperatureto cool
  3. customthe crude brown glass is crystallized from ethanol

Sources & evidence

ORD record
ord-159c8f92594141f89c30f4b9e9361516
Source dataset
uspto-grants-1989_12
Patent number
US04885298

Reaction notes

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