Isobutanol → HCID 19838063, compound

HRID 476641Notes

Reaction equation

HRID 476641 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5](=[O:7])[N:6]=1.[CH2:8](O)[CH:9]([CH3:11])[CH3:10]>>[CH2:8]([O:1][CH:2]1[NH:6][C:5](=[O:7])[CH:4]=[CH:3]1)[CH:9]([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 6560IsobutanolHCID 178516285HCID 178516285, compound

Product 1

HCID 19838063HCID 19838063, compound

Conditions

Temperature
50 °C

Procedure

A mixture of 3 g of 5-hydroxy-2H-pyrrol-2-one and 1.5 g of Amberlite IR 120 H in 60 cm3 of isobutanol, is heated to 50° C. for 3 hours, then cooled and filtered, and the solvent is evaporated. After chromatographing the residue on silica (eluent: ethyl acetate), 4 g of the expected product is obtained.

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. customthe solvent is evaporated

Sources & evidence

ORD record
ord-463bf647f8f1422b9c6c855c71b4f9ea
Source dataset
uspto-grants-1989_12
Patent number
US04885307

Reaction notes

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