反应详情

A solution of 3,4-dimethoxy-5-propylbenzaldehyde (11 g) and sodium borohydride (2 g) in 2-propanol (100 ml) was stirred at room temperature for 2 hours. The mixture was quenched with 2N HCl (200 ml) and extracted with ethyl acetate. The organic phase was separated, washed with brine, dried over MgSO4, filtered and evaporated to leave a yellow oil which was purified by Kugelrohr bulb to bulb distillation at 1 mm Hg air bath temperature 150° to give the sub-title compound as a colorless oil (8 g).

1. customThe mixture was quenched with 2N HCl (200 ml)
2. extractionextracted with ethyl acetate
3. customThe organic phase was separated
4. washwashed with brine
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated
8. customto leave a yellow oil which
9. distillationwas purified by Kugelrohr bulb to bulb distillation at 1 mm Hg air bath temperature 150°