Hydroxyamine hydrochloride → HCID 72728813, compound

HRID 476753Notes

Reaction equation

HRID 476753 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][CH2:12][C:13](O)=O)=[CH:9][C:4]=2[CH2:3][CH2:2]1.Cl.[NH2:17][OH:18].C([O-])(=O)C.[Na+]>C(O)C.O>[O:1]1[CH2:2][CH2:3][C:4]2[CH:9]=[C:8]3[C:7](=[CH:6][C:5]1=2)[C:13](=[N:17][OH:18])[CH2:12][CH2:11][CH2:10]3

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 10679778HCID 10679778, compound

Product 1

HCID 72728813HCID 72728813, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture containing 46 g of the compound of Example 1, 60 g of hydroxylamine hydrochloride and 60 g of anhydrous sodium acetate in 410 ml of ethanol is brought to reflux for 5 hours. The mixture is then cooled and diluted with water, extracted with methylene chloride, dried and evaporated to dryness. The dry residue is recrystallized in ethanol.

Workup

  1. temperatureto reflux for 5 hours
  2. temperatureThe mixture is then cooled
  3. extractionextracted with methylene chloride
  4. customdried
  5. customevaporated to dryness
  6. customThe dry residue is recrystallized in ethanol

Sources & evidence

ORD record
ord-d7c43ddb1d344dc0bbab11c3d6b19feb
Source dataset
uspto-grants-1989_12
Patent number
US04885373

Reaction notes

Loading…