Cyclopropylamine → HCID 178471875, compound

HRID 476775Notes

Reaction equation

HRID 476775 reaction equation
[Cl:1][C:2]1[C:3]([F:22])=[C:4]([CH:17]=[C:18]([F:21])[C:19]=1[F:20])[C:5]([C:7](=[CH:13]OCC)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6].[CH:23]1([NH2:26])[CH2:25][CH2:24]1>C(O)(C)(C)C>[Cl:1][C:2]1[C:3]([F:22])=[C:4]([CH:17]=[C:18]([F:21])[C:19]=1[F:20])[C:5]([C:7](=[CH:13][NH:26][CH:23]1[CH2:25][CH2:24]1)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6]

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 54402571Ethyl 3-ethoxy-2-(3-chloro-2,4,5-trifluorobenzoyl)acrylate

Product 1

HCID 178471875HCID 178471875, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

A solution of 2.7 g (8.0 mmol) of ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-ethoxyacrylate, 0.46 g (8.0 mmol) of cyclopropylamine, and 40 ml of dry t-butanol is stirred at 45° C. for 21/2 hours. The mixture is cooled to room temperature and used without purification in the next step.

Workup

  1. customused without purification in the next step

Sources & evidence

ORD record
ord-1c9082ed52ad425b8d05009c749d5ac2
Source dataset
uspto-grants-1989_12
Patent number
US04885386

Reaction notes

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