Sodium Hydroxide → HCID 131716208, compound

HRID 476794Notes

Reaction equation

HRID 476794 reaction equation
[Cl-].[Ca+2:2].[Cl-].[C:4]([CH2:7][N:8]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15][N:14]([CH2:20][C:21]([OH:23])=[O:22])[CH2:13][CH2:12][N:11]([CH2:24][C:25]([OH:27])=[O:26])[CH2:10][CH2:9]1)([OH:6])=[O:5].[OH-].[Na+]>[99Tc]>[C:4]([CH2:7][N:8]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15][N:14]([CH2:20][C:21]([OH:23])=[O:22])[CH2:13][CH2:12][N:11]([CH2:24][C:25]([OH:27])=[O:26])[CH2:10][CH2:9]1)([OH:6])=[O:5].[Ca+2:2]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 1078301,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecaneHCID 5284359Calcium Chloride

Product 1

HCID 131716208HCID 131716208, compound

Reagents, catalysts & solvents 1

HCID 26476Technetium-99Catalyst

Conditions

Temperature
88 °C

Procedure

100mM of calcium (II) (1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane) was prepared by mixing equal volumes of 200mM of calcium chloride and 200mM of 1,4,7,-triscarboxymethyl-1,4,7,10-tetraazacyclododecane. One and one-half ml of the solution was adjusted to pH 8.8 with dilute sodium hydroxide and 150 μl of 0.88% stannous chloride was added and mixed. Technetium-99m was added to obtain a final concentration of 20 μCi/ml and the solution was adjusted to pH 3. The solution was heated at 88° C. for 20 minutes, cooled, and adjusted to pH 7. After adjusting to a volume of 3 ml, it was passed through a 0.22 μ filter.

Workup

  1. additionwas added
  2. additionmixed
  3. customto obtain a final concentration of 20 μCi/ml
  4. temperaturecooled
  5. filtrationfilter

Sources & evidence

ORD record
ord-bdbb74357a734c248cc43459d201b70a
Source dataset
uspto-grants-1989_12
Patent number
US04885363

Reaction notes

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