Benzylamine → Benzeneacetamide, 4-hydroxy-N-(phenylmethyl)-

HRID 476853Notes

Reaction equation

HRID 476853 reaction equation
CO[C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([NH:20][C:3](=[O:12])[CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

Product 1

HCID 8376026Benzeneacetamide, 4-hydroxy-N-(phenylmethyl)-

Procedure

A mixture of 80 g of 4-hydroxyphenylacetic acid methyl ester and 51.6 g of benzylamine is brought to 180° C. for 8 hours. The mixture is allowed to return to room temperature and the crystals are filtered off and washed with ethanol and then ethyl ether.

Workup

  1. customto return to room temperature
  2. filtrationthe crystals are filtered off
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-467e9f33b6914da9b3e0388437aff99c
Source dataset
uspto-grants-1989_12
Patent number
US04886799

Reaction notes

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