2,3-Dihydroxybutanedioic Acid → 1-Acetyl-4-Methylpiperazine

HRID 476855Notes

Reaction equation

HRID 476855 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[C:8](O)(=O)[CH:9](C(C(O)=O)O)[OH:10]>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:9](=[O:10])[CH3:8])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 531671-Methylpiperazine

Product 1

HCID 5507581-Acetyl-4-MethylpiperazineYield 38%

Procedure

2-(2,3-Dihydro-2-oxo-3-phenyl-5-benzofuranyl)-1-(4-methylpiperazinyl-1-oxoethane was prepared according to the process described in Example 3, but using 4-methylpiperazine in Stage C. The latter compound was dissolved in a solution of DL-tartaric acid to form the corresponding salt, and then recrystallized in ethyl ether.

Workup

  1. customto form the corresponding salt
  2. customrecrystallized in ethyl ether

Sources & evidence

ORD record
ord-09e7a41ec6654d729fc289e12b298cdb
Source dataset
uspto-grants-1989_12
Patent number
US04886799

Reaction notes

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