反应详情

4-[(2R)-2-({[(2S)-2-{[(1,1-Dimethylethyl)(dimethyl)silyl]oxy}-3-(phenyloxy)propyl]amino}methyl)-3,4-dihydro-2H-chromen-6-yl]-2-pyridinecarboxamide (Example 93, 20 mg, 0.04 mmol) was stirred in an excess of 4M HCl in dioxane at room temperature for 30 minutes. The volatile components were removed by rotary evaporation, and the residue was washed with dichloromethane. After drying under vacuum, the title compound was collected as the dihydrochloride salt (8 mg, 43%): MS m/z 434.3 (MH+ of the free base); retention time (LC-MS)=2.02 minutes.

1. customThe volatile components were removed by rotary evaporation
2. washthe residue was washed with dichloromethane
3. customAfter drying under vacuum
4. customthe title compound was collected as the dihydrochloride salt (8 mg, 43%)