5-Methoxytryptamine → 2-[[2-(5-methoxy-1H-indol-3-yl)-ethyl]-amino]-acetonitrile

HRID 476880Notes

Reaction equation

HRID 476880 reaction equation
[CH3:1][O:2][C:3]1[CH:14]=[C:13]2[C:6]([NH:7][CH:8]=[C:9]2[CH2:10][CH2:11][NH2:12])=[CH:5][CH:4]=1.Cl[CH2:16][C:17]#[N:18]>C(N(CC)CC)C>[CH3:1][O:2][C:3]1[CH:14]=[C:13]2[C:6](=[CH:5][CH:4]=1)[NH:7][CH:8]=[C:9]2[CH2:10][CH2:11][NH:12][CH2:16][C:17]#[N:18]

Participants

4

Reactant 2

HCID 18335-MethoxytryptamineHCID 7856Chloroacetonitrile

Product 1

HCID 198370082-[[2-(5-methoxy-1H-indol-3-yl)-ethyl]-amino]-acetonitrile

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Using the procedure of Step A of Example 25, 25 g of 5-methoxytryptamine, 10 ml of chloroacetonitrile and 37 ml of triethylamine were reacted to obtain 20.9 g of the expected product.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-351db71ff3464bcbac167caf5dc137da
Source dataset
uspto-grants-1989_12
Patent number
US04886802

Reaction notes

Loading…