Methylamine → HCID 15594865, compound

Participants

Reaction Steps

0.47 g of the above compound 15 was dissolved in 11 ml of methanol and then 1 ml of methylamine (30% methanol solution) was added dropwise thereto. After stirring overnight at room temperature, the crystalline precipitate was filtered off and recrystallized from ligroin to give 0.38 g of 5-methylamino-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione (compound 16) in a 85% yield.

Provenance & Evidence