Methylamine → HCID 15594865, compound

HRID 476915Notes

Reaction equation

HRID 476915 reaction equation
[C:1]([C:3]1[C:4](=[O:17])[N:5]([CH3:16])[C:6](=[O:15])[N:7]([CH3:14])[C:8]=1[N:9]=[CH:10][N:11](C)C)#[N:2].[CH3:18]N>CO>[CH3:18][NH:2][C:1]1[N:11]=[CH:10][N:9]=[C:8]2[N:7]([CH3:14])[C:6](=[O:15])[N:5]([CH3:16])[C:4](=[O:17])[C:3]=12

Participants

4

Reactant 2

HCID 6329MethylamineHCID 53948848HCID 53948848, compound

Product 1

HCID 15594865HCID 15594865, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.47 g of the above compound 15 was dissolved in 11 ml of methanol and then 1 ml of methylamine (30% methanol solution) was added dropwise thereto. After stirring overnight at room temperature, the crystalline precipitate was filtered off and recrystallized from ligroin to give 0.38 g of 5-methylamino-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione (compound 16) in a 85% yield.

Workup

  1. filtrationthe crystalline precipitate was filtered off
  2. customrecrystallized from ligroin

Sources & evidence

ORD record
ord-8568507012d94042bb8051b5155f08e5
Source dataset
uspto-grants-1989_12
Patent number
US04886807

Reaction notes

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