HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 5-[2-[4-[Bis(4-methoxyphenyl)hydroxymethyl]-1-piperidinyl]ethyl]-3-methyl-2-oxazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | alpha,alpha-Bis(4-methoxyphenyl)-4-piperidinemethanol | HCID 14698742 | — |
| Reactant | 5-(2-Chloro-ethyl)-3-methyl-oxazolidin-2-one | HCID 14698746 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 5-[2-[4-[Bis(4-methoxyphenyl)hydroxymethyl]-1-piperidinyl]ethyl]-3-methyl-2-oxazolidinone | HCID 14698754 | 87% |
Reaction Steps
This compound was prepared according to the procedure of Example 1. A mixture of 3.2 g (0.01 mole) of α,α-bis-(4-methoxyphenyl)-4-piperidinemethanol, 1.6 g (0.01 mole) of 5-(2-chloroethyl)-3-methyl-2-oxazolidinone, 3.7 g (0.035 mole) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 ml of 1-butanol gave 3.9 g (87%) of off-white solid, m.p. 145°-147° C. (2-propanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886794 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-cb12b9f159ea42fa9654a09e3140aa3c |
| Source note | uspto-grants-1989_12 |