Methyl 3-aminocrotonate → HCID 14405152, compound

HRID 476971Notes

Reaction equation

HRID 476971 reaction equation
[NH2:1]/[C:2](/[CH3:8])=[CH:3]\[C:4]([O:6][CH3:7])=[O:5].[F:9][C:10]1([F:28])[O:14][C:13]2[CH:15]=[CH:16][C:17]([C:19](=C)[C:20](=O)[CH2:21][C:22](OC)=O)=[CH:18][C:12]=2[O:11]1>CO>[F:28][C:10]1([F:9])[O:14][C:13]2[CH:15]=[CH:16][C:17]([CH:19]3[C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([CH3:8])[NH:1][C:21]([CH3:22])=[C:20]3[C:4]([O:6][CH3:7])=[O:5])=[CH:18][C:12]=2[O:11]1

Participants

4

Reactant 2

HCID 643918Methyl 3-aminocrotonateHCID 86743568HCID 86743568, compound

Product 1

HCID 14405152HCID 14405152, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

20 mmol of methyl β-aminocrotonate and 20 mmol of crude methyl (2,2-difluoro-1,3-benzodioxol-5-yl)-methylene-acetoacetate are heated under reflux in 30 ml of methanol for 12 hours, the methanol is evaporated off and the residue is chromatographed on silica gel with chloroform. The evaporated product fraction is taken up in a little methylene chloride and the mixture is foamed to a glass by rapid evacuation.

Workup

  1. customthe methanol is evaporated off
  2. customthe residue is chromatographed on silica gel with chloroform

Sources & evidence

ORD record
ord-72625282d90f4b2c9f7ca11ffb26ea1d
Source dataset
uspto-grants-1989_12
Patent number
US04886816

Reaction notes

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