Hydrochloric Acid → HCID 14405135, compound

HRID 476973Notes

Reaction equation

HRID 476973 reaction equation
C([O:4][CH2:5][C:6]1[NH:7][C:8]([CH3:35])=[C:9]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH:10]([C:17]2[C:26]3[O:25][CH:24]([F:27])[C:23]([F:29])([F:28])[O:22][C:21]=3[CH:20]=[CH:19][CH:18]=2)[C:11]=1[C:12]([O:14]CC)=O)(=O)C.Cl>>[CH3:35][C:8]1[NH:7][C:6]2[CH2:5][O:4][C:12](=[O:14])[C:11]=2[CH:10]([C:17]2[C:26]3[O:25][CH:24]([F:27])[C:23]([F:28])([F:29])[O:22][C:21]=3[CH:20]=[CH:19][CH:18]=2)[C:9]=1[C:30]([O:32][CH2:33][CH3:34])=[O:31]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14405134HCID 14405134, compound

Product 1

HCID 14405135HCID 14405135, compound

Procedure

10 mmol of diethyl 2-acetoxymethyl-1,4-dihydro-6-methyl-4-(2,2,3-trifluoro-1,4-benzodioxan-5-yl)-pyridine-3,5-dicarboxylate are heated in 25 mmol of ethanolic hydrochloric acid for 0.5 hour. The solvent is evaporated off and the residue is crystallized in a little ethanol with the addition of petroleum ether.

Workup

  1. customThe solvent is evaporated off
  2. customthe residue is crystallized in a little ethanol with the addition of petroleum ether

Sources & evidence

ORD record
ord-3f95b74650074f2ca2432b40aa4c7370
Source dataset
uspto-grants-1989_12
Patent number
US04886816

Reaction notes

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