HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[(R)-1-ethoxycarbonyl-2pentylthioethyl]-alanyl-(S)-prolyl-(S)-proline t-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[(R)-1-ethoxycarbonyl-2-pentylthioethyl]-alanine | HCID 15595892 | — |
| Reactant | (S)-tert-butyl 1-((S)-pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylate | HCID 15598548 | — |
| Product | N-[(R)-1-ethoxycarbonyl-2pentylthioethyl]-alanyl-(S)-prolyl-(S)-proline t-butyl ester | HCID 70385519 | — |
Reaction Steps
Following the general procedure of Example 27, the title compound was prepared as a colorless oil from 700 mg of the β-isomer of N-[(R)-1-ethoxycarbonyl-2-pentylthioethyl]-alanine prepared in Reference Example 30 and 730 mg of the hydrochloride of (S)-prolyl-(S)-proline t-butyl ester prepared in Reference Example 28. Yield 930 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886813 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-2b1c29ed82014c9ebca5f22dec9db1d2 |
| Source note | uspto-grants-1989_12 |