HRID476986

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCCCCSC[C@H](N[C@@H](C)C(=O)O)C(=O)OCC

HCID15595892

未命名化合物

结构：CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1

HCID15598548

未命名化合物

PRODUCTS

生成物

结构：CCCCCSC[C@H](N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C)C(=O)OCC

HCID70385519

未命名化合物

PROCEDURE

实验过程

Following the general procedure of Example 27, the title compound was prepared as a colorless oil from 700 mg of the β-isomer of N-[(R)-1-ethoxycarbonyl-2-pentylthioethyl]-alanine prepared in Reference Example 30 and 730 mg of the hydrochloride of (S)-prolyl-(S)-proline t-butyl ester prepared in Reference Example 28. Yield 930 mg.

WORKUP

后处理

customprepared in Reference Example 28

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2b1c29ed82014c9ebca5f22dec9db1d2
来源数据集: uspto-grants-1989_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04886813
来源说明: uspto-grants-1989_12

反应 SMILES

[CH2:1]([O:3][C:4]([C@@H:6]([NH:14][C@H:15]([C:17]([OH:19])=O)[CH3:16])[CH2:7][S:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[O:5])[CH3:2].Cl.[C:21]([O:25][C:26](=[O:39])[C@@H:27]1[CH2:31][CH2:30][CH2:29][N:28]1[C:32](=[O:38])[C@@H:33]1[CH2:37][CH2:36][CH2:35][NH:34]1)([CH3:24])([CH3:23])[CH3:22]>>[C:21]([O:25][C:26](=[O:39])[C@@H:27]1[CH2:31][CH2:30][CH2:29][N:28]1[C:32](=[O:38])[C@@H:33]1[CH2:37][CH2:36][CH2:35][N:34]1[C:17](=[O:19])[C@H:15]([CH3:16])[NH:14][C@H:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][S:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])([CH3:24])([CH3:22])[CH3:23]