HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → Ethyl 5-benzylamino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate | HCID 9996650 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 5-benzylamino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate | HCID 14127984 | — |
Reaction Steps
A mixture of ethyl 1-cyclopropyl-5,6,7,8-tetrafluor-1,4-dihydro-4-oxoquinoline-3-carboxylate (28.2 g) prepared in Referential Example 1 (2), benzylamine (9.8 ml), anhydrous potassium carbonate (23.6 g), and acetonitrile (140 ml) was heated at 100°-110° C. for 1 hour to give ethyl 5-benzylamino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline3-carboxylate (21.4 g), which was recrystallized from ethanol, m.p. 134°-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04886810 |
| Source dataset | uspto-grants-1989_12 |
| ORD ID | ord-c9937db3468d4ec89543dcc5c1f8fdde |
| Source note | uspto-grants-1989_12 |