反应详情

A mixture of ethyl 1-cyclopropyl-5,6,7,8-tetrafluor-1,4-dihydro-4-oxoquinoline-3-carboxylate (28.2 g) prepared in Referential Example 1 (2), benzylamine (9.8 ml), anhydrous potassium carbonate (23.6 g), and acetonitrile (140 ml) was heated at 100°-110° C. for 1 hour to give ethyl 5-benzylamino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline3-carboxylate (21.4 g), which was recrystallized from ethanol, m.p. 134°-135° C.

1. temperaturewas heated at 100°-110° C. for 1 hour