反应详情

温度

80 °C

A mixture of 1-cyclopropyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (910 mg), 2-methylpiperazine (320 mg, and pyridine (10 ml) was stirred at 80° C. for 1 hour. After evaporating the reaction mixture under reduced pressure, the residue was dissolved in dilute aqueous ammonia and treated with activated carbon. The filtrate was evaporated under reduced pressure and adjusted to pH 7-8. The resulting crystals were collected by filtration, washed with water, and dried to give 1-cyclopropyl-5,6,8-trifluoro-7-(3-methyl 1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (810 mg), m.p. 235°-237° C.

1. customAfter evaporating the reaction mixture under reduced pressure
2. dissolutionthe residue was dissolved in dilute aqueous ammonia
3. additiontreated with activated carbon
4. customThe filtrate was evaporated under reduced pressure
5. filtrationThe resulting crystals were collected by filtration
6. washwashed with water
7. customdried