Ethyl 1-cyclopropyl-5-ethoxycarbonylamino-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate → Ethyl 7-(3-acetylamino-3-methyl-1-pyrrolidinyl)-1-cyclopropyl5-ethoxycarbonylamino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

HRID 477027Notes

Reaction equation

HRID 477027 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([NH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:10]([F:16])=[C:11](F)[C:12]=3[F:14])[C:7](=[O:23])[C:6]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:5]2)[CH2:3][CH2:2]1.[C:29]([NH:32][C:33]1([CH3:38])[CH2:37][CH2:36][NH:35][CH2:34]1)(=[O:31])[CH3:30]>>[C:29]([NH:32][C:33]1([CH3:38])[CH2:37][CH2:36][N:35]([C:11]2[C:12]([F:14])=[C:13]3[C:8]([C:7](=[O:23])[C:6]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:5][N:4]3[CH:1]3[CH2:3][CH2:2]3)=[C:9]([NH:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:10]=2[F:16])[CH2:34]1)(=[O:31])[CH3:30]

Participants

3

Reactant 2

HCID 15729400Ethyl 1-cyclopropyl-5-ethoxycarbonylamino-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylateHCID 15729401N-(3-methylpyrrolidin-3-yl)acetamide

Product 1

HCID 15729402Ethyl 7-(3-acetylamino-3-methyl-1-pyrrolidinyl)-1-cyclopropyl5-ethoxycarbonylamino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Procedure

In the same manner as described in Example 2 (1), ethyl 1-cyclopropyl-5-ethoxycarbonylamino-6,7,8-trifluoro1,4-dihydro-4-oxoquinoline-3-carboxylate was allowed to react with 3-acetylamino-3-methylpyrrolidine to give ethyl 7-(3-acetylamino-3-methyl-1-pyrrolidinyl)-1-cyclopropyl5-ethoxycarbonylamino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate.

Sources & evidence

ORD record
ord-3db21fd632d24bed99bd5236e92ba43a
Source dataset
uspto-grants-1989_12
Patent number
US04886810

Reaction notes

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