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Ethyl 1-cyclopropyl-5-ethoxycarbonylamino-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate → Ethyl 7-(3-acetylamino-3-methyl-1-pyrrolidinyl)-1-cyclopropyl5-ethoxycarbonylamino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 1-cyclopropyl-5-ethoxycarbonylamino-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate | HCID 15729400 | — |
| 反応物 | N-(3-methylpyrrolidin-3-yl)acetamide | HCID 15729401 | — |
| 生成物 | Ethyl 7-(3-acetylamino-3-methyl-1-pyrrolidinyl)-1-cyclopropyl5-ethoxycarbonylamino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate | HCID 15729402 | — |
反応手順
In the same manner as described in Example 2 (1), ethyl 1-cyclopropyl-5-ethoxycarbonylamino-6,7,8-trifluoro1,4-dihydro-4-oxoquinoline-3-carboxylate was allowed to react with 3-acetylamino-3-methylpyrrolidine to give ethyl 7-(3-acetylamino-3-methyl-1-pyrrolidinyl)-1-cyclopropyl5-ethoxycarbonylamino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04886810 |
| 出典データセット | uspto-grants-1989_12 |
| ORD ID | ord-3db21fd632d24bed99bd5236e92ba43a |
| 出典メモ | uspto-grants-1989_12 |