Hydrochloric Acid → 5-Amino-7-(3-amino-3-methyl-1-pyrroldinyl)-1-cyclopropyl6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride

Participants

Reaction Steps

A mixture of ethyl 7-(3-acetylamino-3-methyl1-pyrroldinyl)-1-cyclopropyl-5-ethoxycarbonylamino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate, 20% aqueous sodium hydroxide, and ethanol was refluxed for 12 hours. The reaction mixture was treated with activated carbon and adjusted at pH 1-2 with 10% hydrochloric acid. After cooling, the resulting crystals were collected by filtration and recrystallized from water-ethanol to give 5-amino-7-(3-amino-3-methyl-1-pyrroldinyl)-1-cyclopropyl6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride, m.p. 293°-297° C. (decomp.).

Provenance & Evidence