反应详情

A mixture of ethyl 7-(3-acetylamino-3-methyl1-pyrroldinyl)-1-cyclopropyl-5-ethoxycarbonylamino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate, 20% aqueous sodium hydroxide, and ethanol was refluxed for 12 hours. The reaction mixture was treated with activated carbon and adjusted at pH 1-2 with 10% hydrochloric acid. After cooling, the resulting crystals were collected by filtration and recrystallized from water-ethanol to give 5-amino-7-(3-amino-3-methyl-1-pyrroldinyl)-1-cyclopropyl6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride, m.p. 293°-297° C. (decomp.).

1. temperaturewas refluxed for 12 hours
2. additionThe reaction mixture was treated with activated carbon
3. temperatureAfter cooling
4. filtrationthe resulting crystals were collected by filtration
5. customrecrystallized from water-ethanol