HCID 19974265, compound → N-[2-(4-(2-Carbomethoxy-1-methylethenyl) phenyl)-1-methylethyl]-2-(2-trifluoromethyl-thiazol-4-yl)morpholine

HRID 477118Notes

Reaction equation

HRID 477118 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[S:4][CH:5]=[C:6]([CH:8]2[O:13][CH2:12][CH2:11][NH:10][CH2:9]2)[N:7]=1.[C:16]([CH:20]=[C:21]([C:23]1[CH:28]=[CH:27][C:26]([CH2:29][C:30](=O)[CH3:31])=[CH:25][CH:24]=1)[CH3:22])([O:18][CH3:19])=[O:17]>>[C:16]([CH:20]=[C:21]([C:23]1[CH:28]=[CH:27][C:26]([CH2:29][CH:30]([N:10]2[CH2:11][CH2:12][O:13][CH:8]([C:6]3[N:7]=[C:3]([C:2]([F:14])([F:1])[F:15])[S:4][CH:5]=3)[CH2:9]2)[CH3:31])=[CH:25][CH:24]=1)[CH3:22])([O:18][CH3:19])=[O:17]

Participants

3

Reactant 2

HCID 19974265HCID 19974265, compoundHCID 545480031-[4-(2-Carbomethoxy-1-methylethenyl)phenyl]propan-2-one

Product 1

HCID 54361252N-[2-(4-(2-Carbomethoxy-1-methylethenyl) phenyl)-1-methylethyl]-2-(2-trifluoromethyl-thiazol-4-yl)morpholine

Procedure

Prepared analogously to Example 13 by reaction of 2-(2-trifluoromethyl-thiazol-4-yl)morpholine with 1-[4-(2-carbomethoxy-1-methylethenyl)phenyl]propan-2-one followed by purification of the base on a silica gel column using chloroform/ethyl acetate=19:1 as eluant.

Workup

  1. customfollowed by purification of the base on a silica gel column

Sources & evidence

ORD record
ord-62544046cf964ed58ddbc4728bd1f256
Source dataset
uspto-grants-1989_12
Patent number
US04886814

Reaction notes

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