Triethylsilane → HCID 19974138, compound

HRID 477123Notes

Reaction equation

HRID 477123 reaction equation
O[CH2:2][CH2:3][NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=1.[F:15][C:16]([F:27])([F:26])[C:17]1[S:18][CH:19]=[C:20]([C:22](=[O:25])[CH2:23]Br)[N:21]=1.C([SiH](CC)CC)C>>[CH3:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][N:4]2[CH2:3][CH2:2][O:25][CH:22]([C:20]3[N:21]=[C:17]([C:16]([F:27])([F:26])[F:15])[S:18][CH:19]=3)[CH2:23]2)=[CH:8][CH:9]=1

Participants

4

Reactant 3

HCID 12052TriethylsilaneHCID 10978660HCID 10978660, compoundHCID 199743272-{[2-(4-Methoxyphenyl)ethyl]amino}ethan-1-ol

Product 1

HCID 19974138HCID 19974138, compound

Procedure

Prepared analogously to Example 32 by reaction of N-(2-hydroxyethyl)-2-(4-methoxyphenyl)ethanamine with 2-trifluoromethyl-4-bromoacetyl-thiazole followed by reduction with triethylsilane.

Sources & evidence

ORD record
ord-0a4e095c29614321986dd0b49ab762de
Source dataset
uspto-grants-1989_12
Patent number
US04886814

Reaction notes

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