反应详情

0.21 g (0.005 mol) of N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethylthiazol-4-yl) ethanamine is dissolved in 10 ml of butan-2-one, and 0.5 ml of ethyl bromoacetate and 0.5 g of potassium carbonate are added, and the mixture is stirred at room temperature for 16 hours. The inorganic products are removed by filtration, and the solvent is removed by distillation. The remaining oil is purified on a silica gel column using toluene/ethyl acetate=85:15 as eluant. A colourless oil is obtained.

1. customThe inorganic products are removed by filtration
2. customthe solvent is removed by distillation
3. customThe remaining oil is purified on a silica gel column
4. customA colourless oil is obtained