Hydrochloric Acid → HCID 22747938, compound
Reaction equation
C([NH:5][C:6]([NH:8][CH:9]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=1)[CH2:10]O)=[S:7])(C)(C)C.[ClH:21]>>[ClH:21].[N+:18]([C:14]1[CH:13]=[C:12]([CH:9]2[CH2:10][S:7][C:6]([NH2:5])=[N:8]2)[CH:17]=[CH:16][CH:15]=1)([O-:20])=[O:19]Participants
3
Conditions
- Temperature
- 100 °C
Procedure
The process is performed as in Example 2, starting with 4.77 g of N-(tert-butyl)-N′-[2-hydroxy-1-(3-nitrophenyl)ethyl]thiourea and 44 cm3 of aqueous 6N hydrochloric acid, and this mixture is maintained at a temperature in the region of 100° C. for 2 h 30 min. After an identical work-up, 3.1 g of 4-(3-nitrophenyl)-4,5-dihydro-1,3-thiazol-2-ylamine hydrochloride are obtained in the form of a cream-colored solid melting at 232° C.
Sources & evidence
- ORD record
- ord-4424d7cac7064c52aaffeba455a012c7
- Source dataset
- uspto-grants-2004_03
- Patent number
- US06699895B2
Reaction notes
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