Water → HCID 72727347, compound

HRID 477186Notes

Reaction equation

HRID 477186 reaction equation
[OH:1][N:2]=[C:3]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.[OH2:18].[CH3:19][N:20](C)[CH:21]=[O:22]>>[OH:1][N:2]=[C:3]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([C:17]([C:12]2[CH:13]=[C:14]3[C:19](=[CH:4][CH:3]=2)[NH:20][C:21](=[O:22])[CH2:16][CH2:15]3)=[O:18])[CH2:10][CH2:11]1

Participants

4

Reactant 3

HCID 962WaterHCID 6228DimethylformamideHCID 85555412HCID 85555412, compound

Product 1

HCID 72727347HCID 72727347, compound

Procedure

127 Milligrams of succinimide 3,4-dihydrocarbostyril-6-carbostyril-6-carboxylate and 123 mg of (3-hydroxyimino-3-phenylpropyl)piperazine were dissolved in 2 ml of dimethylformamide, then this mixture was stirred for 24 hours. To the reaction mixture was added water, then extracted with chloroform and this extracted was washed with water and with an aqueous solution saturated with sodium chloride. Next, the washed extract was dried with anhydrous potassium carbonate, then the solvent was removed by evaporation under reduced pressure. The residue thus obtained was recrystallized from ethanol to yield 102 mg of 6-[4-(3-hydroxyimino-3-phenylpropyl)-1-piperazinylcarbonyl]-3,4-dihydrocarbostyril.semihydrate. White powdery substance.

Workup

  1. extractionextracted with chloroform
  2. washthis extracted was washed with water and with an aqueous solution saturated with sodium chloride
  3. extractionNext, the washed extract
  4. dry with materialwas dried with anhydrous potassium carbonate
  5. customthe solvent was removed by evaporation under reduced pressure
  6. customThe residue thus obtained
  7. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-b4e202a2038445e5b465219d122630df
Source dataset
uspto-grants-1989_12
Patent number
US04886809

Reaction notes

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