HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → N-[(1S)-2-hydroxy-1-(3-nitrobenzyl)ethyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 53755981 | HCID 53755981 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[(1S)-2-hydroxy-1-(3-nitrobenzyl)ethyl]acetamide | HCID 69698133 | 95.4% |
Reaction Steps
The process is performed as in Example 2, starting with 7.15 g of ethyl (2S)-2-(acetylamino)-3-(3-nitrophenyl)propanoate and 1.46 g of sodium borohydride in 70 cm3 of ethanol. After an identical work-up, 5.8 g of N-[(1S)-2-hydroxy-1-(3-nitrobenzyl)-ethyl]acetamide are obtained in the form of a white solid melting at 131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699895B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-1cd3757d15404d4dae993ba458c8f512 |
| Source note | uspto-grants-2004_03 |