反应详情

A solution of 25.0 grams (g) 4,6-dimethyl-2-mercaptopyrimidine, 25.1 g 4-fluoronitrobenzene and 24.6 g potassium carbonate in 750 milliliters (ml) acetonitrile was refluxed for 16 hours. The solution was then filtered hot through a pad of dicalite. The dicalite was washed with 300 ml hot acetonitrile. The solvent was evaporated from the combined filtrates giving a waxy yellow solid. This solid was triturated with hexanes giving 42.5 g yellow solid.

1. filtrationThe solution was then filtered hot through a pad of dicalite
2. washThe dicalite was washed with 300 ml hot acetonitrile
3. customThe solvent was evaporated from the combined filtrates
4. customgiving a waxy yellow solid
5. customThis solid was triturated with hexanes giving 42.5 g yellow solid