反应详情

A stirred mixture of 11.0 g of 4-amino-5-imidazolecarboxamide hydrochloride and 15.0 g of 3-dimethylaminoacrylophenone (prepared as described in Example 1) in 120 ml of glacial acetic acid was heated at reflux for 4 hours. The solvent was evaporated in vacuo to give a dark oil which was dissolved in dichloromethane, then treated by stirring with saturated sodium bicarbonate. The organic solvent was evaporated and the remaining mixture was filtered and the solid was washed with water, dried, and then was recrystallized from ethanol to give 7.08 g of the desired product as a yellow solid, mp 226°-228° C.

1. temperaturewas heated
2. temperatureat reflux for 4 hours
3. customThe solvent was evaporated in vacuo
4. customto give a dark oil which
5. additiontreated
6. customThe organic solvent was evaporated
7. filtrationthe remaining mixture was filtered
8. washthe solid was washed with water
9. customdried
10. customwas recrystallized from ethanol