反应详情

To a solution of 9.2 g of 4-(α,α,α-trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-carboxamide (Ex. 28, U.S. Pat. No. 4,236,005) in 100 ml of glacial acetic acid, was added in portions 3.0 g of sodium cyanoborohydride at room temperature under nitrogen. The mixture was stirred at room temperature for 3 hours. The solvent was evaporated in vacuo to give an oil. The oil was triturated with water and a white precipitate formed, and this was collected by filtration, washed with water and then was slurried with saturated sodium bicarbonate solution. The precipitate was again collected by filtration and washed with water. This solid was dissolved in dichloromethane, and then water was added. The organic layer was separated, dried over anhydrous sodium sulfate and filtered. Evaporation of the filtrate gave a yellow solid which was recrystallized from acetonitrile to give 7.0 g of the product of the example as a light yellow solid, mp 192°-194° C.

1. customThe solvent was evaporated in vacuo
2. customto give an oil
3. customThe oil was triturated with water
4. customa white precipitate formed
5. filtrationthis was collected by filtration
6. washwashed with water
7. filtrationThe precipitate was again collected by filtration
8. washwashed with water
9. dissolutionThis solid was dissolved in dichloromethane
10. additionwater was added
11. customThe organic layer was separated
12. dry with materialdried over anhydrous sodium sulfate
13. filtrationfiltered
14. customEvaporation of the filtrate
15. customgave a yellow solid which
16. customwas recrystallized from acetonitrile