Hydrazine hydrate (1:1) → HCID 178429720, compound

HRID 477535Notes

Reaction equation

HRID 477535 reaction equation
C[O:2][C:3]([C:5]1[N:15]=[C:8]2[N:9]=[C:10]([CH3:14])[CH:11]=[C:12]([SH:13])[N:7]2[N:6]=1)=O.O.[NH2:17][NH2:18]>CO>[NH:17]([C:3]([C:5]1[N:15]=[C:8]2[N:9]=[C:10]([CH3:14])[CH:11]=[C:12]([SH:13])[N:7]2[N:6]=1)=[O:2])[NH2:18]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178499048HCID 178499048, compound

Product 1

HCID 178429720HCID 178429720, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 2-methoxycarbonyl-7-mercapto5-methyl-s-triazolo[1,5-a]pyrimidine (10 g) in 200 ml of methanol was dropwise added hydrazine hydrate (110 ml). The mixture was stirred at room temperature for two hours, the insoluble matters were filtered off, and the solvent was removed by distillation from the filtrate. Water (100 ml) was added to the residue and the pH was adjusted to 4.0 with 1N hydrochloric acid. The formed crystals were collected by filtration and washed with 100 ml of water, then with 100 ml of methanol, affording 7.2 g of the objective compound as yellow crystals.

Workup

  1. filtrationthe insoluble matters were filtered off
  2. customthe solvent was removed by distillation from the filtrate
  3. additionWater (100 ml) was added to the residue
  4. filtrationThe formed crystals were collected by filtration
  5. washwashed with 100 ml of water

Sources & evidence

ORD record
ord-a1c5eb340b4c4c3c84e470cd1559bc68
Source dataset
uspto-grants-1989_12
Patent number
US04888332

Reaction notes

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