Dimethylformamide → HCID 178499052, compound

HRID 477536Notes

Reaction equation

HRID 477536 reaction equation
C[C:2]([CH2:4][C:5]([O:7]CC)=O)=[S:3].[NH2:10][C:11]1[N:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[NH:13][N:12]=1.[CH3:20]N(C)C=O>>[OH:7][C:5]1[CH:4]=[C:2]([S:3][CH3:20])[N:12]2[N:13]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[N:15]=[C:11]2[N:10]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 77201Methyl 5-amino-1H-1,2,4-triazole-3-carboxylateHCID 11744773Butanoic acid, 3-thioxo-, ethyl ester

Product 1

HCID 178499052HCID 178499052, compound

Procedure

A suspension of ethyl 2-methylthiocarbonylacetate (37.6 g) an 3-amino-5-methoxycarbonyl-s-triazole (20 g) in dimethylformamide (200 ml) was refluxed for one hour. After removing the solvent by distillation under reduced pressure, ether was added to the residue, and the formed crystals were purified by silica gel chromatography, giving 11.7 g of the objective compound.

Workup

  1. temperaturewas refluxed for one hour
  2. customAfter removing the solvent
  3. distillationby distillation under reduced pressure, ether
  4. additionwas added to the residue
  5. customthe formed crystals were purified by silica gel chromatography

Sources & evidence

ORD record
ord-efa7ebad225549ce9a2693be3a2dc9b4
Source dataset
uspto-grants-1989_12
Patent number
US04888332

Reaction notes

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